CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? Gloves, eye protection and a dust mask should be used. Avicel PC 611 (FMC Biopolymer) Supplied by. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. lH5JWy}DgKRR"Fs 5 0 obj Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . l~5C LOT #: Available upon request. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. MATERIAL SAFETY DATA SHEET. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. Are you sure you want to delete your template? w !1AQaq"2B #3Rbr <> Learn about FMC's industry leading goal of net-zero emissions by 2035. stream 1. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. ( At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Watch Now. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? >> Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. 1 0 obj These grades have particle sizes ranging from <30 to approximately 200. 2021 Annual Report. No. All rights reserved. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. The short-term limit for total inhalable dust is 20 mg/m3. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream FMC, JRS and Mingtai were estimated to hold for . SCMm_>x^O9l (n. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. endobj In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. Test Data Available. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . endobj CAS #: 9004-34-6 1.6. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. %PDF-1.5 Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. 3 0 obj Document(s): certificate data msds. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. } !1AQa"q2#BR$3br The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. /MediaBox [0 0 612 792] : 1. High performance lubricant that brings more to the tablet. gac74 [#B6`Wnw7 : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? : 5. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. Revision No. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. (1962). Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. CAS 9004-34-6. Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. Molecular weight: Not Applicable 1.5. Powder becomes slippery when wet. endobj Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm Avicel Microcrystalline Cellulose Physical Properties. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication (&E. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. xv}O2' H~KEe9>G/,:9\i In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. The cellulose molecule is formed through repeated condensation of cellobiose units. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. It works as a moisture sponge and permits the controlled growth of spheroids. : 160182 Date Approved: 05/25/2010 Revision No. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. It is available in different grades and particle sizes. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Superior Performance: Provides excellent water uptake and rapid swelling . Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. We respect your privacy FMC Privacy Policy. All Rights Reserved. endobj Page 1 of 8. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Instead, they obtained a stable colloidal suspension. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. 6 0 obj Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Van Veen, G.K. Bolhuis, Y.S. Avicel PC 611 (FMC Biopolymer) . Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . MCC helps in the formation of spheres because of its . pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no PDF (2.77 mb) 2021 FMC Sustainability Report. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! ( Meet our leadership team. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. Manufacturer: FMC BioPolymer. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. <> <> Your file is uploaded and ready to be published. Combines good flow and high compactibility. }o]X4]. CAS #: 9004-34-6 . Avicel PC 611 Microcrystalline Cellulose. : 9004-34-6 Date Approved: 01/31/2008 . << GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. In large quantities it provides dietary bulk and may lead to a laxative effect. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . . They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. endstream A family of polysaccharide products that allow distinctive drug delivery solutions. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Micro Crystalline Cellulose. 4. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. No. stream HMo@9, U Q!R/1*;` Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. It is a white, free-flowing powder. Hi, let us know if you have any questions as you visit our website. MATERIAL SAFETY DATA SHEET Version: 1.0 1. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B .
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